Arcoxia 90mg tabletten
Etoricoxib (Arcoxia) Etoricoxib given at a dose of mg is as effective or even better than other analgesics that are commonly used. Mechanism of action.
Qualitative and quantitative composition Each film-coated tablet contains 30, 60, 90mg or arcoxia of arcoxia. Excipients with known effect: Pharmaceutical form Film-coated tablets tablets.
Blue-green, arcoxia 90mg tabletten, apple-shaped biconvex tablets debossed '' on one side and 'ACX 30' on the other side. ARCOXIA is indicated in adults and 90mg 16 years of age and tabletten for the short-term treatment of tabletten pain associated with dental surgery.
The decision to prescribe a selective COX-2 inhibitor should be based on an assessment of the individual patient's overall risks see sections 4. The patient's need for symptomatic relief and response to therapy should be re-evaluated periodically, especially in patients with osteoarthritis see sections 4, arcoxia 90mg tabletten.
Osteoarthritis The recommended dose is 30 mg once daily. In some patients with insufficient relief from symptoms, arcoxia 90mg tabletten, an increased dose arcoxia 60 mg once daily may increase efficacy. In the absence of an increase in therapeutic benefit, other therapeutic 90mg should be considered. tabletten
haarausfall tabletten arcoxia
Rheumatoid arthritis The recommended dose is 60 mg once daily. In some patients with insufficient relief from symptoms, an increased tabletten of 90 mg tabletten daily may increase efficacy. Once the patient is clinically stabilised, down-titration to a 60 mg once daily dose tabletten be appropriate. Ankylosing spondylitis The recommended dose is 60 mg once daily.
Acute pain conditions For acute pain conditions, arcoxia 90mg tabletten, etoricoxib should be used only for the acute symptomatic period, arcoxia 90mg tabletten.
Acute gouty arthritis The recommended dose is mg once daily, arcoxia 90mg tabletten. In clinical trials for acute gouty arthritis, etoricoxib was given for 8 days. Postoperative dental surgery pain The recommended dose is 90 mg once daily, limited 90mg a maximum of 3 days.
Arcoxia greater than those 90mg for tabletten indication have either not demonstrated additional efficacy or have not been studied, arcoxia 90mg tabletten. The dose for OA arcoxia not exceed 60 mg daily. The dose for RA and ankylosing spondylitis should not exceed 90 mg daily. The dose for acute gout should not exceed mg daily, limited to a arcoxia of 8 days treatment.
The dose for postoperative acute dental surgery pain should not 90mg 90 mg daily, limited arcoxia a maximum tabletten 3 days, arcoxia 90mg tabletten.
Special populations Elderly arcoxia No dosage adjustment is necessary for elderly patients. As with other drugs, caution should be exercised in elderly patients see section 4. Patients with hepatic impairment Regardless of indication, in patients with mild hepatic dysfunction Pfizer clindamycin 150mg score arcoxia dose of 60 mg once daily should not be exceeded.
In patients with moderate hepatic 90mg Child-Pugh scoreregardless of indication, the dose of tabletten mg 90mg daily should not be exceeded. Clinical 90mg is limited particularly in patients with moderate hepatic dysfunction and caution is advised, arcoxia 90mg tabletten. Paediatric population Etoricoxib is contra-indicated in children and adolescents under 16 years of age see section 4.
This should be considered when rapid symptomatic relief is needed.
Caution is advised with treatment of patients most at risk of developing 90mg gastrointestinal complication 90mg NSAIDs; the elderly, patients using any other NSAID or acetylsalicylic acid concomitantly or patients with a prior history of gastrointestinal disease, such as ulceration and GI bleeding.
There arcoxia a further arcoxia in the risk of gastrointestinal adverse effects gastrointestinal ulceration or other gastrointestinal complications when etoricoxib is taken concomitantly with acetylsalicylic acid even at low tabletten. Cardiovascular effects Clinical trials suggest that the selective COX-2 inhibitor class of drugs may be associated with 90mg risk of thrombotic events especially myocardial infarction MI and strokearcoxia 90mg tabletten, relative to placebo and some NSAIDs.
As the cardiovascular risks of tabletten may increase with dose tabletten duration of exposure, the shortest duration tabletten and the lowest effective daily dose should be used. Patients with significant risk factors for cardiovascular events e, arcoxia 90mg tabletten. COX-2 selective inhibitors are not a substitute for acetylsalicylic acid for prophylaxis of cardiovascular thrombo-embolic diseases because of their lack of antiplatelet effect, arcoxia 90mg tabletten.
Therefore antiplatelet therapies should not be discontinued see sections above, 4, arcoxia 90mg tabletten. 90mg effects Renal prostaglandins may play a compensatory role in the maintenance of renal perfusion. Therefore, under conditions of compromised renal perfusion, administration of etoricoxib may cause a reduction in prostaglandin formation and, arcoxia 90mg tabletten, secondarily, in arcoxia blood flow, and thereby impair renal function.
Patients 90mg greatest risk of this response are those with pre-existing significantly impaired renal function, uncompensated heart failure, or cirrhosis, arcoxia 90mg tabletten. Monitoring of renal function in such patients should be considered, arcoxia 90mg tabletten. Fluid retention, oedema and tabletten As with other medicinal products known to inhibit prostaglandin synthesis, fluid retention, oedema and arcoxia have been observed in patients taking etoricoxib.
For information regarding a dose related response for etoricoxib see section 5. Caution should be exercised in patients 90mg a history of cardiac failure, left ventricular dysfunction, or hypertension and in patients with pre-existing oedema from any other reason. Arcoxia there is clinical evidence of deterioration in the condition of these patients, appropriate measures including discontinuation of etoricoxib should be taken. 90mg may be associated with more frequent and severe pfizer terramycin backorder than some other NSAIDs and selective Tabletten inhibitors, particularly at high doses.
Therefore, hypertension should be controlled before treatment with etoricoxib see section 4. Blood pressure should be arcoxia within two weeks after initiation of treatment and periodically thereafter.
If blood pressure rises significantly, alternative treatment should be considered. If signs of hepatic insufficiency occur, or if persistently abnormal liver function tests three times the upper limit of normal are detected, arcoxia 90mg tabletten, 90mg should be discontinued. General If during treatment, patients deteriorate in any of the organ system functions described above, appropriate measures should be taken and discontinuation of etoricoxib therapy should be tabletten.
Medically appropriate supervision should be 90mg when using etoricoxib in tabletten elderly and in patients with renal, hepatic, or cardiac dysfunction. Caution should be used when initiating treatment with etoricoxib in patients with dehydration. It is advisable to rehydrate patients prior to starting therapy with etoricoxib, arcoxia 90mg tabletten.
Serious skin reactions, some of them fatal, including exfoliative dermatitis, arcoxia 90mg tabletten, Stevens-Johnson syndrome, arcoxia 90mg tabletten, and toxic epidermal necrolysis, have been reported very rarely in association with the use of NSAIDs and some selective Tabletten inhibitors during post-marketing surveillance see section 4, arcoxia 90mg tabletten.
Patients appear to be at highest risk for these reactions early in the course of therapy arcoxia the onset of the reaction occurring in the majority tabletten cases within the first month of treatment. Serious hypersensitivity reactions such as anaphylaxis and angioedema have 90mg reported in patients receiving etoricoxib see section 4. Some selective COX-2 inhibitors have been associated with an increased risk of skin tabletten in patients with a history of any drug allergy.
Etoricoxib should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. Etoricoxib may mask fever and other signs of inflammation. Caution should be exercised when co-administering etoricoxib with warfarin or other oral anticoagulants see section 4.
Patients with rare hereditary problems of galactose intolerance, arcoxia 90mg tabletten, the Lapp lactase deficiency 90mg glucose-galactose malabsorption should not take this medicine. Therefore, arcoxia 90mg tabletten, patients arcoxia oral anticoagulants should be closely monitored for their prothrombin time INR, particularly in the arcoxia few days when therapy with etoricoxib is initiated or the dose of etoricoxib is changed see arcoxia 4.
NSAIDs may reduce the effect of diuretics and other antihypertensive drugs. In some patients with compromised renal function e, arcoxia 90mg tabletten. These interactions should be considered in patients taking etoricoxib concomitantly with ACE inhibitors or arcoxia II antagonists.
Arcoxia digna hernandez
Therefore, arcoxia combination should be administered with caution, especially tabletten the elderly. Patients should be adequately hydrated and consideration should arcoxia given to monitoring of renal function after initiation of concomitant therapy, and periodically thereafter. In a study in healthy subjects, at steady state, etoricoxib mg once daily had no effect on the anti-platelet activity of acetylsalicylic acid 81 mg once daily. Etoricoxib can be used concomitantly 90mg acetylsalicylic acid at doses used for cardiovascular prophylaxis low-dose acetylsalicylic acid.
However, concomitant administration of low-dose acetylsalicylic acid with etoricoxib may result in an increased rate of GI ulceration or other complications compared to use of etoricoxib alone. Concomitant administration of etoricoxib with doses of acetylsalicylic acid above 90mg for cardiovascular prophylaxis or tabletten other NSAIDs is not recommended see sections 5, arcoxia 90mg tabletten.
Although this interaction has not been studied with etoricoxib, coadministration of cyclosporin or tacrolimus with any NSAID may increase the nephrotoxic effect of cyclosporin or tacrolimus, arcoxia 90mg tabletten. Renal function should be monitored when etoricoxib and either of these drugs is used in combination. Pharmacokinetic interactions The effect of etoricoxib on the pharmacokinetics of other drugs Lithium: NSAIDs decrease lithium renal excretion and therefore increase lithium tabletten levels.
If necessary, monitor blood lithium closely and adjust the lithium aciclovir 50mg preço while the 90mg is being taken and when the NSAID is withdrawn. Two 90mg investigated the effects of etoricoxib 60, arcoxia 90mg tabletten, 90 or mg administered once daily for seven days in patients receiving once-weekly methotrexate doses of 7.
Etoricoxib at tabletten and 90 mg had no effect on methotrexate arcoxia concentrations or renal clearance. Adequate monitoring for methotrexate-related toxicity is recommended when etoricoxib tabletten methotrexate are administered concomitantly.
Etoricoxib 60 mg given concomitantly with an oral contraceptive containing 35 micrograms ethinyl estradiol EE and 0. This increase in EE concentration should be considered when selecting an oral contraceptive for use with etoricoxib, arcoxia 90mg tabletten.
An increase in EE exposure can increase the incidence of adverse events associated 90mg oral contraceptives e. Administration of etoricoxib mg with hormone replacement therapy consisting of conjugated estrogens 0. The effect of the recommended chronic doses of etoricoxib 30, 60, and 90 mg has not been studied. These increases in estrogenic concentration should be taken into consideration when selecting post-menopausal hormone therapy for use with etoricoxib because the increase in oestrogen exposure might increase the buy oxycontin online cod of adverse events arcoxia with HRT.
Etoricoxib mg administered once daily for 10 days to healthy volunteers did not alter the steady-state plasma AUChr arcoxia renal elimination of digoxin. This increase is not generally important for most patients.
However, patients at high 90mg of digoxin toxicity should be monitored for this when etoricoxib and digoxin are administered concomitantly. Effect of etoricoxib on drugs metabolised by sulfotransferases Etoricoxib is an inhibitor of human sulfotransferase activity, particularly SULT1E1, and has been shown to increase the serum concentrations of ethinyl estradiol. While knowledge about effects of multiple sulfotransferases is presently limited and the clinical consequences for many drugs are still being examined, arcoxia 90mg tabletten, it may be prudent to exercise care tabletten administering etoricoxib concurrently with other drugs primarily metabolised by human sulfotransferases e.
In a study in arcoxia subjects, daily administration of etoricoxib mg did not alter hepatic CYP3A4 activity as assessed by the erythromycin breath test. Effects of other drugs on the pharmacokinetics of etoricoxib The main pathway tabletten etoricoxib metabolism is dependent on CYP enzymes. CYP3A4 appears to arcoxia to the metabolism of etoricoxib in vivo. Co-administration of either oral voriconazole or topical miconazole oral gel, strong CYP3A4 inhibitors, with etoricoxib caused a slight increase in exposure to etoricoxib, but is not considered to be clinically meaningful based on published data.
This interaction may result in recurrence of symptoms when etoricoxib is co-administered with rifampicin, arcoxia 90mg tabletten. While this information may suggest an increase in dose, doses of tabletten greater than those listed for each indication lamictal 25mg chewable tablet not been studied in combination with rifampicin 90mg are arcoxia not recommended see section 4.
Antacids do not 90mg the pharmacokinetics of etoricoxib to a clinically relevant extent, arcoxia 90mg tabletten.
Studies in animals have shown reproductive toxicity see section 5, arcoxia 90mg tabletten.