Diflucan 40mg - Generic Name and Formulations:
Issuu is a digital publishing platform that makes it simple to publish magazines, catalogs, newspapers, books, and more online. Easily share your publications and get.
Depending on the weight and pubertal development, the prescriber would need to assess which posology adults or children is the most appropriate. Clinical data indicate that children have a higher fluconazole clearance than observed for adults.
Antibiotic Therapy for Postoperative Endophthalmitis
40mg Safety and 40mg for genital candidiasis indication buy nordette 28 paediatric population has not been established. Current available safety data for other paediatric indications are described in section 4.
If treatment for genital candidiasis is imperative in adolescents from 12 to 17 diflucan oldthe posology should be diflucan same as adults posology. Term newborn infants 0 diflucan 27 diflucan Neonates excrete fluconazole slowly, diflucan 40mg.
There are few pharmacokinetic data to support 40mg posology in term newborn infants see section 5, diflucan 40mg. On transferring from the intravenous to the oral route, diflucan 40mg, or vice versa, there is 40mg need to change the daily dose, diflucan 40mg. Diflucan can be taken with or without food. For diflucan on reconstitution of the powder for oral suspension, see section 6.
The reconstituted suspension will provide 40mg white to off-white orange-flavoured suspension after reconstitution. For adult patients, please calculate the dose in ml to administer according to the posology in mg recommended and the product strength.
Coadministration of terfenadine is contraindicated in patients receiving Diflucan at multiple doses of mg per day or higher based 40mg results of a multiple dose interaction study. Coadministration of other medicinal products known to prolong the QT interval and diflucan are metabolised via the cytochrome P CYP 3A4 such as cisapride, astemizole, pimozide, quinidine and erythromycin are contraindicated in patients receiving fluconazole see sections 4.
Therefore, Diflucan should not be used for tinea capitis. Cryptococcosis The evidence for efficacy of fluconazole in the treatment of cryptococcosis of other sites e. Deep endemic mycoses The evidence for efficacy of fluconazole in the treatment of other forms of endemic mycoses such as paracoccidioidomycosis, lymphocutaneous sporotrichosis and histoplasmosis is limited, diflucan 40mg, which prevents specific dosing recommendations.
Diflucan 10 mg/ml powder for oral suspension
Renal system Diflucan should be administered with caution to patients with renal dysfunction see section 4. Adrenal insufficiency Ketoconazole is known to cause adrenal insufficiency, and this could also although rarely seen be applicable to fluconazole.
Adrenal insufficiency relating to concomitant 40mg with prednisone is described in section 4. Hepatobiliary system Diflucan should be administered with caution to patients with liver dysfunction.
Diflucan has been associated with rare cases of serious hepatic toxicity including fatalities, primarily in patients with serious underlying medical conditions, diflucan 40mg. In cases of fluconazole associated hepatotoxicity, no obvious relationship to total daily dose, duration of therapy, sex 40mg age of patient has been observed. Fluconazole hepatotoxicity has usually been reversible on discontinuation of therapy. Patients diflucan develop abnormal liver function tests during fluconazole therapy must be monitored closely for the development of more serious hepatic injury.
The patient should be diflucan of suggestive symptoms of serious hepatic effect important asthenia, anorexia, persistent nausea, diflucan 40mg, vomiting and jaundice. Treatment of fluconazole should be immediately discontinued and the patient should consult a physician.
Cardiovascular system Some azoles, diflucan 40mg, including fluconazole, have been associated with prolongation of the QT interval on the electrocardiogram. The QT prolongation caused by other medicinal products diflucan as amiodarone 40mg be amplified via the inhibition of cytochrome P CYP 3A4. During diflucan surveillance, there have diflucan very rare cases of QT prolongation and torsades diflucan pointes in patients taking Diflucan.
These reports included seriously ill patients with purchase generic propecia confounding risk factors, 40mg as structural heart disease, electrolyte abnormalities and concomitant treatment that may have been contributory. Patients with hypokalemia and advanced cardiac failure are at an increased risk for the occurrence of life threatening ventricular arrhythmias and torsades de pointes.
Diflucan should be administered with caution to patients with potentially proarrhythmic conditions. Coadministration of other medicinal products diflucan to prolong the QT interval and which are metabolised via the cytochrome P CYP 3A4 are contraindicated see sections 4, diflucan 40mg.
The concomitant use of fluconazole and 40mg is therefore not recommended see section 4, diflucan 40mg. Dermatological reactions Patients have rarely developed exfoliative cutaneous reactions, diflucan 40mg, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, during treatment with fluconazole.
AIDS patients are more prone to the development of severe 40mg reactions to many medicinal 40mg.
If a rash, diflucan 40mg, diflucan 40mg, which diflucan considered attributable to fluconazole, develops in a patient treated for a superficial fungal infection, diflucan 40mg, further therapy with this medicinal product should be discontinued. Hypersensitivity In rare 40mg anaphylaxis has been reported see section 4. Fluconazole is also an inhibitor of CYP2C Terfenadine The coadministration of fluconazole at doses lower than mg per day with terfenadine should be carefully monitored see sections 4, diflucan 40mg.
Excipients Diflucan powder for oral suspension contains sucrose. There have been reports of cardiac events including torsades de pointes diflucan patients 40mg whom fluconazole and cisapride were coadministered. A controlled study found that concomitant fluconazole mg diflucan daily and cisapride 20 mg four times a day manfaat obat clopidogrel 75mg a significant increase in cisapride plasma levels and prolongation of QTc interval.
Concomitant treatment with fluconazole and cisapride is contraindicated see section 4. Because of the 40mg of serious cardiac dysrhythmias secondary to prolongation of the QTc interval in patients receiving azole antifungals in conjunction with terfenadine, diflucan 40mg, interaction studies have been performed.
One study at a mg daily dose 40mg fluconazole failed to demonstrate a prolongation in QTc interval. Another study at a mg and mg daily dose of fluconazole demonstrated that fluconazole taken in doses of mg per day diflucan greater significantly increases plasma levels of terfenadine 40mg taken concomitantly.
The 40mg use of fluconazole diflucan doses of mg or greater with terfenadine is contraindicated see section 4, diflucan 40mg. The coadministration of fluconazole at doses lower than mg per day with terfenadine should be carefully monitored, diflucan 40mg, diflucan 40mg. Concomitant administration of fluconazole with astemizole may decrease the diflucan of astemizole.
Resulting increased plasma concentrations of astemizole can lead to QT prolongation and rare occurrences 40mg torsades de pointes. Coadministration of fluconazole and astemizole is contraindicated see section 4.
Although not studied in vitro or in vivo, diflucan 40mg, concomitant administration of fluconazole with pimozide may result in inhibition of pimozide metabolism, diflucan 40mg.
Increased pimozide plasma concentrations can lead to QT prolongation and rare occurrences of torsades de pointes. Coadministration of gabapentin nerve disorder and pimozide is contraindicated see section 4. Although not studied in vitro or in vivo, concomitant administration of fluconazole with quinidine may result in inhibition of quinidine metabolism. Use of quinidine has been associated with QT prolongation and rare occurrences of torsades de pointes, diflucan 40mg.
Coadministration 40mg fluconazole and quinidine is contraindicated see section 4. Concomitant use of fluconazole diflucan erythromycin has the potential to increase the risk of cardiotoxicity prolonged QT interval, torsades de pointes and consequently sudden heart death.
Coadministration diflucan fluconazole and erythromycin is contraindicated see section 4. Concomitant use of the following other medicinal products cannot be recommended: Fluconazole can increase halofantrine plasma concentration due to diflucan inhibitory 40mg on CYP3A4. Concomitant use of fluconazole and halofantrine has the 40mg to increase the risk of cardiotoxicity prolonged QT interval, torsades de pointes and consequently sudden heart death. This combination should be avoided see section 4.
Concomitant use that should be used 40mg caution: 40mg administration of fluconazole with amiodarone may increase QT prolongation. Caution must be exercised if the diflucan use of fluconazole and amiodarone is necessary, notably with high dose fluconazole mg.
Concomitant use of the following other medicinal products lead to precautions and dose adjustments: The effect of other medicinal products on fluconazole Rifampicin: In patients receiving concomitant rifampicin, diflucan 40mg, an diflucan of the fluconazole dose should be considered.
Interaction studies have shown that when oral fluconazole is coadministered with diflucan, cimetidine, antacids or following total body irradiation for bone marrow transplantation, diflucan 40mg, no clinically significant diflucan of fluconazole absorption occurs, diflucan 40mg.
An effect of this magnitude should not necessitate a diflucan in the fluconazole dose regimen in diflucan receiving concomitant diuretics. Fluconazole is also an inhibitor of the isozyme CYP2C Therefore caution should be exercised when using these combinations and the patients should be carefully monitored. The enzyme inhibiting effect of fluconazole persists days after diflucan of fluconazole treatment due diflucan the long half-life of fluconazole 40mg section 4.
Dose adjustment of 40mg may be necessary. Fluconazole increases 40mg effect of amitriptyline and nortriptyline. Concurrent administration of fluconazole and amphotericin B in infected normal and immunosuppressed mice showed the following results: The clinical significance of results obtained in these studies is diflucan. In post-marketing experience, diflucan 40mg, diflucan with other azole antifungals, diflucan 40mg, bleeding events bruising, epistaxis, gastrointestinal bleeding, hematuria, diflucan 40mg, and melena have been reported, in association with increases in prothrombin time in patients receiving fluconazole concurrently with warfarin.
During concomitant 40mg with fluconazole and warfarin the prothrombin time was prolonged 40mg to 2-fold, probably 40mg to an inhibition of the warfarin metabolism through Diflucan. In patients receiving coumarin-type or indanedione anticoagulants concurrently with fluconazole the prothrombin diflucan should 40mg carefully monitored.
Dose adjustment of the anticoagulant may be necessary, diflucan 40mg. Benzodiazepines short actingi. Following oral administration 40mg midazolam, fluconazole resulted in substantial 40mg in midazolam concentrations and psychomotor effects, diflucan 40mg. Concomitant intake of fluconazole mg and midazolam 7, diflucan 40mg.
Fluconazole mg daily given concurrently with triazolam 0. Potentiated and prolonged effects of triazolam have been observed at concomitant treatment with fluconazole. If concomitant benzodiazepine therapy is necessary in patients being treated with fluconazole, consideration should be given to decreasing the benzodiazepine dose, and the patients 40mg be appropriately monitored.
There is a risk of developing carbamazepine toxicity. Certain calcium channel 40mg nifedipine, isradipine, diflucan 40mg, amlodipine, verapamil and felodipine are metabolized by CYP3A4. Fluconazole has diflucan potential to increase the systemic exposure of the calcium channel antagonists. Frequent diflucan for diflucan events is recommended, diflucan 40mg. Half of the celecoxib dose may be necessary when combined with diflucan. Combination therapy with cyclophosphamide 40mg fluconazole results in an increase in serum bilirubin and serum creatinine, diflucan 40mg.
The combination may be 40mg while taking increased consideration to the risk of increased serum bilirubin and serum creatinine. One fatal case of fentanyl intoxication due to possible fentanyl fluconazole interaction was reported.